Chinese Teenager Becomes Youngest Ever Patient to be Diagnosed with Alzheimer’s

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A teenager from China has become the world’s youngest patient to be given a probable diagnosis of Alzheimer’s.

The 19-year-old, believed to be from Beijing, had been experiencing symptoms for two years including memory loss, difficulty concentrating, delayed reactions and reading difficulties.

By the time he visited doctors at the Capital Medical University in Beijing, he could not even remember what he’d had for dinner the previous day and had to withdraw from his final year at high school. 

Tests and scans revealed that his hypothalamus, an area of the brain that plays a role in cognition, had shrunk. He also showed damage to his temporal lobe and elevated levels of a protein called tau, both hallmarks of Alzheimer’s. 

Doctors who published the case report last month were puzzled when they found he had no family history or the genetic mutation usually found in very young Alzheimer’s patients.

They said, “This is the youngest case ever reported to meet the diagnostic criteria for probable [Alzheimer’s disease] without recognized genetic mutations.”

Alzheimer’s typically afflicts people 65 and older. Diagnoses before age 65 make up roughly five to 10 percent of all Alzheimer’s cases. 

Previously, the youngest person to be diagnosed with Alzheimer’s was 21 years old and had a genetic mutation. 

There have been several other unusual early-onset diagnoses. For instance,  Worcestershire, England native Jordan Adams was diagnosed at age 24. 

Daniel Bradbury, also from England, was diagnosed at 30 and has since passed away. And Rebecca Doig, an Australian, was diagnosed at 31 and has also died.

The Beijing team’s findings build upon a growing amount of scientific study into more rapid diagnostics that can detect telltale signs of the disease years before symptoms manifest. 

The researchers’ findings cast doubt on the traditional understanding of Alzheimer’s as a disease of the elderly.

They said, “[The study] proposed to pay attention to the early-onset Alzheimer’s disease. 

“Exploring the mysteries of young people with Alzheimer’s disease may become one of the most challenging scientific questions of the future.”

The case study was published in the Journal of Alzheimer’s Disease on January 31.

Alzheimer’s is the most common form of dementia. The condition is chronic and worsens over time, typically killing people between three and 11 years after the initial diagnosis.

But Alzheimer’s can remain in the shadows for years without manifesting symptoms in a phase researchers call preclinical Alzheimer’s disease. Symptoms are not visible to anyone in this phase, which can last decades.

Neuroscientists have been working consistently for years to develop an Alzheimer’s diagnostic tool that can detect the disease earlier, such as an inexpensive blood test capable of detecting nerve cell damage specific to the brain to measure neurodegeneration. An earlier diagnosis opens the door for earlier treatment, raising the patient’s chances of surviving longer.

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